[Selective effects of pulmonary surfactant on various subpopulations of alveolar macrophages in the model of experimental tuberculosis].
Vestn Ross Akad Med Nauk
; (11): 22-8, 2012.
Article
em Ru
| MEDLINE
| ID: mdl-23457977
ABSTRACT
Pulmonary surfactant is necessary component for maintenance of high level of phagocytic activity of alveolar macrophages. Tuberculosis inflammation reduces the production of surfactant by type II cells and phagocytic activity of alveolar macrophages. The effects of exogenous pulmonary surfactant on the ultrastructural changes of various subpopulations of alveolar macrophages were studied by TEM-method. For investigations the bronchial alveolar lavage fluid from guinea pigs infected of M. tuberculosis and treated by isoniatid or isoniazid + exogenous pulmonary surfactant were used. It was shown that isoniazid + exogenous pulmonary surfactant normalizes the heterogeneous population of alveolar macrophages providing stimulating effects on their maturation and phagocytic activity more effectively than isoniazid therapy.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Surfactantes Pulmonares
/
Macrófagos Alveolares
Idioma:
Ru
Ano de publicação:
2012
Tipo de documento:
Article