FBH1 protects melanocytes from transformation and is deregulated in melanomas.
Cell Cycle
; 12(7): 1128-32, 2013 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-23466708
ABSTRACT
FBH1 is a member of the UvrD family of DNA helicases and plays a crucial role in the response to DNA replication stress. In particular, upon DNA replication stress, FBH1 promotes double-strand breakage and activation of the DNA-PK and ATM signaling cascades in a helicase-dependent manner. In the present manuscript, we show that FBH1 is often deleted or mutated in melanoma cells, which results in their increased survival in response to replicative stress. Accordingly, FBH1 depletion promotes UV-mediated transformation of human melanocytes. Thus, FBH1 inactivation appears to contribute to oncogenic transformation by allowing survival of cells undergoing replicative stress due to external factors such as UV irradiation.
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Base de dados:
MEDLINE
Assunto principal:
DNA Helicases
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Proteínas de Ligação a DNA
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Melanócitos
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Melanoma
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article