Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase.
Chem Commun (Camb)
; 49(49): 5535-7, 2013 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-23476925
N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 µM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH-lactate dehydrogenase (LDH) is also reported.
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Base de dados:
MEDLINE
Assunto principal:
Transferases
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Haemophilus influenzae
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Inibidores Enzimáticos
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Ácidos Hidroxâmicos
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Antibacterianos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article