Clinical evaluation of ß-TCP in the treatment of lacunar bone defects: a prospective, randomized controlled study.
Mater Sci Eng C Mater Biol Appl
; 33(4): 1894-9, 2013 May 01.
Article
em En
| MEDLINE
| ID: mdl-23498210
ABSTRACT
The aim of this study was to investigate the potential wide application of beta tricalcium phosphate (ß-TCP) only for bone defects as compared to allograft. 95 patients with a solitary bone cyst were randomly assigned to the treatment. A new radiographic scoring system was employed to calculate the biodegradation of bone graft and to evaluate the influence of multiple factors. At an average of 28.43 months after surgery, a radiographic semi-quantitative analysis revealed that the degradation rates of ß-TCP and the allograft were comparable (p>0.05). Age, complication, packing methods and granule diameters have a significant influence on ß-TCP degradation. The loose packing method and 3-5mm granule size should be employed in clinical practice. A histological analysis of biopsy showed that ß-TCP supported the growth of fibrous tissue, vascular tissue, as well as bone tissue into the implants. The results proved that single ß-TCP is an advantageous alternative to allografts for lacunar bone defect repair and would well guide the design and clinical application of the ß-TCP.
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Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
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Cistos Ósseos
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Fosfatos de Cálcio
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article