Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population.
Mitochondrion
; 13(4): 263-8, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23528301
ABSTRACT
Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n=422) and IDC patients (n=304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value=0.040).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
DNA Mitocondrial
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Cardiomiopatia Dilatada
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article