1,8-Naphthalimide-Cu(ÐÐ) ensemble based turn-on fluorescent probe for the detection of thiols in organic aqueous media.
Bioorg Med Chem Lett
; 23(9): 2538-42, 2013 May 01.
Article
em En
| MEDLINE
| ID: mdl-23545110
ABSTRACT
A 1,8-naphthalimide-Cu(II) ensemble was rationally designed and synthesized as a new turn-on fluorescent probe utilizing the 'chemosensing ensemble' method for detections of thiols (Cys, Hcy and GSH) with high selectivity over other α-amino acids at pH 7.4 in organic aqueous media (EtOH/HEPES, v/v=91). The recognition mechanism was attributed to the remove Cu(II) from the 1,8-naphthalimide-Cu(II) ensemble by thiols and the release of flurescence of ligand 1. Remarkable fluorescence enhancements were therefore observed in the sensing process of thiols by the 1,8-naphthalimide-Cu(II) ensemble. Furthermore, the 1,8-naphthalimide-Cu(II) ensemble was successfully applied to the fluorescence imaging of thiols in CHO cells with high sensitivity and selectivity.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
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Cobre
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Naftalimidas
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Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article