5-Oxo-ETE receptor antagonists.
J Med Chem
; 56(9): 3725-32, 2013 May 09.
Article
em En
| MEDLINE
| ID: mdl-23581530
ABSTRACT
5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Ácidos Araquidônicos
/
Receptores Eicosanoides
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article