Decreased serum 5-oxoproline in TB patients is associated with pathological damage of the lung.
Clin Chim Acta
; 423: 5-9, 2013 Aug 23.
Article
em En
| MEDLINE
| ID: mdl-23608301
ABSTRACT
BACKGROUND:
Tuberculosis (TB) is a serious world-wide health problem, causing millions of deaths every year. Metabolomics is a relatively new approach to identify disease specific biomarkers. However, there is little information available on metabolite biomarkers in TB. In this study, we used gas chromatography/time-of-flight mass spectrometry (GC/TOF-MS) to identify serum metabolite biomarkers associated with the active state of TB.METHODS:
Potential biomarkers were selected by comparing serum metabolites in 10 healthy donors with 10TB patients, and in 6TB patients before and after treatment. Selected biomarkers were then validated using a larger population of samples from 120 healthy donors and 120TB patients derived from different clinical backgroundsRESULTS:
The 5-oxoproline level was consistently low in patients with active TB. Further validation in larger population of clinical samples showed that 5-oxoproline was associated with pathological damage of the lung but not with age, sex, or bacterial burden in TB patients.CONCLUSIONS:
Serum 5-oxoproline may be a useful biomarker for active TB and pathological damage of the lung.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Pirrolidonocarboxílico
/
Tuberculose
/
Pulmão
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article