Repeated administration of AC-5216, a ligand for the 18 kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder.
Prog Neuropsychopharmacol Biol Psychiatry
; 45: 40-6, 2013 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-23624119
Palavras-chave
1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 18kDa translocator protein; 18kDa translocator protein (TSPO); AC-5216; ANOVA; Allopregnanolone; CBR; CNS; EPM; Freezing behavior; GABA(A); HPA; IMM; N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl) acetamide; OF; OMM; PK11195; PTSD; Post-traumatic stress disorder (PTSD); SBSSs; SPS; SRs; SSRIs; ST; Ser; TSPO; analysis of variance; central benzodiazepine receptor; central nervous system; elevated plus-maze; gamma-amino-butyric acid type A receptor; hypothalamicpituitaryadrenal; inner mitochondrial membrane; open field; outer mitochondrial membrane; post-traumatic stress disorder; selective brain steroidogenic stimulants; selective serotonin reuptake inhibitors; sertraline; single prolonged stress; situational reminders; staircase test
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Purinas
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Transtornos de Estresse Pós-Traumáticos
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Ansiolíticos
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Sintomas Comportamentais
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Receptores de GABA
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article