Anti-HIV and NO production inhibition activities of epi-aleuritolic acid derivatives.
J Asian Nat Prod Res
; 15(5): 515-24, 2013.
Article
em En
| MEDLINE
| ID: mdl-23639006
ABSTRACT
Fifteen epi-aleuritolic acid derivatives were synthesized and evaluated for anti-HIV activity in 293 T cells and NO production inhibition activity. Of the derivatives, 1, 2, 3, 4, 11, and 13 showed relatively potent anti-HIV activity with EC50 values ranging from 5.80 to 13.30 µM. The most potent compound, 3α-2',2'-dimethylsuccinic acyl epi-aleuritolic acid (11), displayed significant anti-HIV activity with an EC50 value of 5.80 µM. Compounds 1, 3, 4, and 11 showed NO inhibition activity, with IC50 values ranging from 3.40 to 7.10 µM and compound 1 inhibited NO production with an IC50 value of 3.40 µM.
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1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Palmíticos
/
Fármacos Anti-HIV
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Óxido Nítrico
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article