Involvement of translation and transcription processes into neurophysiological mechanisms of long-term memory reconsolidation.
Bull Exp Biol Med
; 154(5): 584-7, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23658873
ABSTRACT
We studied the involvement of translation and transcription processes into behavioral and neuronal mechanisms of reconsolidation of the long-term memory of the conditioned taste aversion in edible snails. Injection of cycloheximide (an inhibitor of protein synthesis) to the snails in 48 h after training combined with subsequent reminder and presentation of the conditional stimulus resulted in the development of persistent amnesia and depression of the responses of the defensive behavior command neurons LPl1 and RPl1 to the conditional stimulus. Injection of mRNA synthesis inhibitors actinomycin D or DRB (5,6-dichloro-1-ß-D-ribofuranosylbenzimidasole) in 48 h after conditioning with subsequent reminding procedure produced no effects on memory retention and on the responses of the command neurons to the conditional stimulus. The study suggests that the proteins translated from previously synthesized and stored mRNA were involved in the mechanisms of reconsolidation of the memory responsible for conditioned taste aversion.
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Biossíntese de Proteínas
/
Condicionamento Clássico
/
Memória de Longo Prazo
/
Caracois Helix
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article