Ectopic neuroblastoma in monozygotic twins with different ages of onset: possible twin-to-twin metastasis in utero with distinct genetic alterations after birth.
J Pediatr Hematol Oncol
; 36(2): 166-8, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-23669722
ABSTRACT
We describe neuroblastoma (NB) in monozygotic twins whose ages at the onset of the disease had a 3-year interval. The primary tumor site of twin 1 was the adrenal gland, whereas that of twin 2 was the jejunum/mesentery. MYCN amplification, DNA index, ALK mutation, and copy number alterations of DNA were different between each primary tumor. NB in ectopic sites may have resulted from twin-to-twin metastasis through vascular anastamoses in the placenta. The pathogenesis of this NB involved a premalignant stage of NB during the fetal development and subsequent molecular alterations after birth, resulting in NBs that were phenotypically similar but genetically different.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Gêmeos Monozigóticos
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Neoplasias das Glândulas Suprarrenais
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Doenças em Gêmeos
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Neoplasias Gastrointestinais
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Neuroblastoma
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article