Effects of Shenshao Decoction on the inflammatory response in the aorta of a rat atherosclerotic model.
Chin J Integr Med
; 19(5): 347-52, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23674111
ABSTRACT
OBJECTIVE:
To investigate the effect of Shenshao Decoction on the inflammatory status in the aorta in a rat model of atherosclerosis.METHODS:
Forty Sprague-Dawley rats were randomly divided into five groups, 8 rats in each group control untreated group, atherosclerosis group, atherosclerosis with Shenshao Decoction (low dose) group, atherosclerosis with Shenshao Decoction (high dose) group, atherosclerosis with simvastatin group. To stimulate atherosclerosis, the rats were fed vitamin D3 and a high-cholesterol diet. Four weeks later, treatments were maintained for eight weeks. Morphology changes were investigated by hematoxylin and eosin staining. Serum levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were obtained by enzymatic assays with use of an automated biochemical analyzer. The expression of malondialdehyde (MDA), glutathione peroxidase (GSH-PX) were detected by enzyme-enzymelinked immunosorbent assay. The expression levels of interleukin (IL)-1ß, IL-17A, and IL-23 were detected by linked immunoblotting.RESULTS:
Shenshao Decoction treatment decreased TC, TG, LDL-C and MDA and increased GSH-PX levels (P<0.01). Compared with the control group, IL-1ß, IL-17A, and IL-23 were lower in the high andCONCLUSION:
Shenshao Decoction could attenuate the progression of aortal atherosclerotic plaques by inhibiting the inflammatory response in a rat atherosclerotic model.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aorta Torácica
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Medicamentos de Ervas Chinesas
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Aterosclerose
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Inflamação
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article