Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones.
Molecules
; 18(5): 5580-93, 2013 May 15.
Article
em En
| MEDLINE
| ID: mdl-23676469
ABSTRACT
A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosforanos
/
Quinazolinas
/
Éteres
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article