Rocuronium and sugammadex in patients with myasthenia gravis undergoing thymectomy.
Acta Anaesthesiol Scand
; 57(6): 745-8, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23678983
ABSTRACT
BACKGROUND:
The use of neuromuscular blocking agents is still controversial in myasthenic patients but rocuronium could be useful after the introduction of sugammadex as a selective antagonist. The aim of the study was to evaluate the use of rocuronium-sugammadex in myasthenic patients undergoing thoracoscopic thymectomy.METHODS:
After ethical approval, 10 myasthenic patients undergoing videothoracoscopic-assisted thymectomy were enrolled in the study. Neuromuscular block was achieved with 0.3 mg/kg rocuronium and additional doses were given according to train-of-four (TOF) monitoring or movement of the diaphragm. Sugammadex 2 mg/kg was given after surgery. Recovery time (time to obtain a TOF value > 0.9) was recorded for all subjects.RESULT:
All patients were extubated in the operating room after administration of sugammadex. Mean rocuronium dose was 48 mg and the average operation time was 62 min. Recovery time after sugammadex administration was 111 s (min 35; max 240).CONCLUSIONS:
A rapid recovery of neuromuscular function was found in myasthenic patients receiving rocuronium when sugammadex was used for reversal. This combination could be a rational alternative for myasthenic patients for whom neuromuscular blockade is mandatory during surgery.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Timectomia
/
Timoma
/
Neoplasias do Timo
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Fármacos Neuromusculares não Despolarizantes
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Bloqueio Neuromuscular
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Cirurgia Torácica Vídeoassistida
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Gama-Ciclodextrinas
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Androstanóis
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Miastenia Gravis
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article