Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses.
J Neuropsychiatry Clin Neurosci
; 25(2): 134-40, 2013.
Article
em En
| MEDLINE
| ID: mdl-23686031
ABSTRACT
The authors explored cross-sectional associations between MRI parameters (lesion metrics, brain volumes, magnetization transfer ratio histograms, and metabolite concentrations) and cognition in 61 patients who experienced clinically-isolated syndromes (CIS) 7 years earlier. IQ decline and poorer overall cognition were associated with T2 white-matter lesions, and slow information-processing with both T2 lesions and gray-matter atrophy. In a previous study of the same cohort, gray-matter atrophy measured shortly after CIS failed to predict development of cognitive impairment years later. Our findings suggest that gray-matter pathology, reflected by atrophy measurements, becomes increasingly important in determining cognition as MS progresses.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Imageamento por Ressonância Magnética
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Transtornos Cognitivos
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Progressão da Doença
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article