Protein equilibration through somatic ring canals in Drosophila.
Science
; 340(6139): 1445-7, 2013 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-23704373
ABSTRACT
Although intercellular bridges resulting from incomplete cytokinesis were discovered in somatic Drosophila tissues decades ago, the impact of these structures on intercellular communication and tissue biology is largely unknown. In this work, we demonstrate that the ~250-nanometer-diameter somatic ring canals permit diffusion of cytoplasmic contents between connected cells and across mitotic clone boundaries and enable the equilibration of protein between transcriptionally mosaic follicle cells in the Drosophila ovary. We obtained similar, although more restricted, results in the larval imaginal discs. Our work illustrates the lack of cytoplasmic autonomy in these tissues and suggests a role for somatic ring canals in promoting homogeneous protein expression within the tissue.
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Base de dados:
MEDLINE
Assunto principal:
Estruturas Citoplasmáticas
/
Transporte Proteico
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Citoplasma
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Proteínas de Drosophila
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Proteínas de Fluorescência Verde
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Discos Imaginais
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article