[The relationship between salivary protein's change and dental caries].

PURPOSE: To evaluate the relationship between salivary protein's change and dental caries in patients after oral administration of glucocorticoid. METHODS: Sixty patients were divided equally into the experimental group and the control group. The mixed saliva samples of the experimental group before (T1) and after (T2) taking GC orally, as well as the baseline(C1) and after 12 months(C2) of the control group were collected. IgA, LDH, LZM were examined in both groups. The decayed-missing-filled surface (DMFS), decayed-missing-filled tooth(DMFT), caries severity index(CSI) in both groups were recorded. All statistical analyses were performed using SPSS17.0 software package. RESULTS: After taking GC orally, the concentration of IgA and LZM were significantly lower than the control group(P<0.01), while the concentration of LDH was significantly higher than the control group(P<0.01). Before and after taking GC orally, the salivary protein's change was significantly correlated with DMFT,DMFS and CSI. CONCLUSIONS: After taking glucocorticoid orally , the concentration of LZM, IgA, LDH in saliva changes. LZM, IgA, LDH take part in the occurrence and development of dental caries as the important part of oral immunization.