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Ventilatory response to hypoxia of the 1-day old chicken hatchling after prenatal cold-induced hypometabolism.
Mortola, Jacopo P; Toro-Velasquez, Paula Andrea.
Afiliação
  • Mortola JP; Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. jacopo.mortola@mcgill.ca
Respir Physiol Neurobiol ; 188(2): 161-4, 2013 Aug 15.
Article em En | MEDLINE | ID: mdl-23747276
Sustained prenatal hypoxia decreases the growth and metabolic rate of the embryo and causes a blunted hypoxic ventilatory response (HVR) in the newborn. The most likely interpretation is that the sustained hypoxic stimulation may interfere with the normal prenatal development of the chemoreceptors. However, we wanted to consider the possibility that the prolonged hypoxic hypometabolism may be a contributing factor. Chicken embryos were incubated at 35°C (Cold group, N=14), which is known to lower the embryonic oxygen consumption (VO2) by ≈ 30% throughout incubation, or at 37.5°C (Controls, N=16). Cold incubation delayed hatching by ≈ 2 days. The 1-day old hatchlings had normal pulmonary ventilation (VE), measured by the barometric technique, and oxygen consumption (VO2), simultaneously measured by an open flow methodology. During acute hypoxia (≈ 15% or ≈ 11% O2) the hyperventilation (increase in VO2), the hyperpnea and the hypometabolism were almost identical between the two groups of hatchlings. We conclude that a sustained decrease in metabolic rate during the embryonic period by itself does not carry obvious consequences on the newborn's resting VE and HVR.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Temperatura Baixa / Ventilação Pulmonar / Hipóxia / Doenças Metabólicas Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Temperatura Baixa / Ventilação Pulmonar / Hipóxia / Doenças Metabólicas Idioma: En Ano de publicação: 2013 Tipo de documento: Article