FGFR fusions in the driver's seat.
Cancer Discov
; 3(6): 607-9, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23749526
ABSTRACT
Through a clinical deep sequencing protocol, Wu and colleagues have identified multiple FGFR fusion proteins in diverse cancers. Pharmacologic inhibition of FGFR suppressed the growth of FGFR fusion-positive tumor models, suggesting that these FGFR fusions are oncogenic drivers and highlighting the use of streamlined clinical sequencing efforts to identify novel, actionable driver oncoproteins in human tumors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Fusão Oncogênica
/
Receptores de Fatores de Crescimento de Fibroblastos
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Neoplasias
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article