Synthesis of ß-C-GlcNAc Ser from ß-C-Glc Ser.
J Org Chem
; 78(13): 6798-801, 2013 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-23767880
ABSTRACT
The glycosylation of proteins, specifically installation of O-GlcNAc on Ser/Thr residues, is a dynamic control element for transcription repression, protein degradation, and nutrient sensing. To provide homogeneous and stable structures with this motif, the synthesis of a C-linked mimic, C-GlcNAc Ser, has been prepared from the C-Glc Ser by a double inversion strategy using azide to insert the C-2 nitrogen functionality. The C-Glc Ser was available by a ring-closing metathesis and hydroalkoxylation route.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilglucosamina
/
Serina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article