Polymer gene delivery vectors encapsulated in thermally sensitive bioreducible shell.
Bioorg Med Chem Lett
; 23(14): 4080-4, 2013 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-23768908
ABSTRACT
Stable, nanosized polyelectrolyte complexes between rationally designed thermally sensitive block copolymers and plasmid DNA (polyplexes) were formed and their in vitro transfection efficiency was tested. The polyplexes were further stabilized through encapsulation into a biodegradable polymer shell. Although reduced as compared to that of the corresponding polyplexes, the encapsulated systems still show acceptable transfection efficiency. That opens the possibility to tune the balance between the safe transport and efficient delivery of DNA into the cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Vetores Genéticos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article