In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus.
Asian Pac J Trop Med
; 6(8): 595-601, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23790329
ABSTRACT
OBJECTIVE:
To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis.METHODS:
The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis (M. philippinensis) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus (E. granulosus), under in-vitro conditions with reference to the known standard drug Praziquantel®.RESULTS:
At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation.CONCLUSIONS:
As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Mallotus (Planta)
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Echinococcus granulosus
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Frutas
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Anti-Helmínticos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article