2-D strain assessment in the mouse through spatial compounding of myocardial velocity data: in vivo feasibility.
Ultrasound Med Biol
; 39(10): 1848-60, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23830981
Ultrasound assessment of myocardial strain can provide valuable information on regional cardiac function. However, Doppler-based methods often used in practice for strain estimation suffer from angle dependency. In this study, a partial solution to that fundamental limitation is presented. We have previously reported using simulated data sets that spatial compounding of axial velocities obtained at three steering angles can theoretically outperform 2-D speckle tracking for 2-D strain estimation in the mouse heart. In this study, the feasibility of the method was analyzed in vivo using spatial compounding of Doppler velocities on six mice with myocardial infarction and five controls, and results were compared with those of tagged microscopic magnetic resonance imaging (µMRI). Circumferential estimates quantified by means of both ultrasound and µMRI could detect regional dysfunction. Between echocardiography and µMRI, a good regression coefficient was obtained for circumferential strain estimates (r = 0.69), whereas radial strain estimates correlated only moderately (r = 0.37). A second echocardiography was performed after µMRI to test the reproducibility of the compounding method. This yielded a higher correlation coefficient for the circumferential component than for the radial component (r = 0.74 circumferentially, r = 0.49 radially).
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MEDLINE
Assunto principal:
Algoritmos
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Interpretação de Imagem Assistida por Computador
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Ecocardiografia Doppler
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Função Ventricular Esquerda
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Técnicas de Imagem por Elasticidade
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Ventrículos do Coração
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Contração Miocárdica
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article