Quantification of circulating Epstein-Barr virus DNA in NK/T-cell lymphoma treated with the SMILE protocol: diagnostic and prognostic significance.
Leukemia
; 28(4): 865-70, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-23842425
ABSTRACT
Circulating Epstein-Barr virus (EBV) DNA is a biomarker of EBV-associated malignancies. Its significance in natural killer/T-cell lymphoma treated with the novel regimen SMILE was investigated. EBV DNA was quantified with a World Health Organization EBV standard in 910 plasma samples collected during 230 courses of SMILE in 56 patients. Median presentation EBV DNA was 1900 (0-1.4 × 10(7)) IU/ml. Presentation EBV DNA was significantly associated with tumor load and treatment response. To examine lymphoma chemosensitivity, EBV DNA changes after SMILE were evaluated. EBV DNA after SMILE (I) significantly correlated with tumor load and treatment response. Two dynamic parameters were further analyzed negative EBV DNA after SMILE (I) and EBV DNA change patterns during treatment (A persistently undetectable; B persistently detectable
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Base de dados:
MEDLINE
Assunto principal:
DNA Viral
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Células Matadoras Naturais
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Protocolos de Quimioterapia Combinada Antineoplásica
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Linfoma de Células T
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Herpesvirus Humano 4
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article