Apolipoprotein E genotypes associated with Alzheimer disease and concomitant stroke.
J Stroke Cerebrovasc Dis
; 23(4): 681-5, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-23871727
ABSTRACT
BACKGROUND:
The É4 allele of the apolipoprotein E (APOE) gene is a well-characterized genetic risk factor for Alzheimer disease (AD). The association between stroke and a higher risk for AD has also been reported. Our study sought to determine the relationship between the APOE gene and AD and the comorbid risk of stroke.METHODS:
The subjects of this study consisted of 48 patients with AD and 48 members of a control group. All subjects were genotyped for APOE.RESULTS:
The results clearly show a significant increased risk of AD in carriers of the APOE ε3/ε4 genotype (P = .003, odds ratio [OR] = 4.1) or ε4 allele (P = .001, OR = 4.2). The risk for stroke in AD patients was also increased for carriers of the APOE ε3/ε4 genotype (P = .02, OR = 9.0) and for carriers of the APOE ε4 allele (P = .004, OR = 5.5).CONCLUSIONS:
The present study is the first to establish a relationship between APOE ε4 and concomitant AD and stroke in the Tunisian population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Acidente Vascular Cerebral
/
Doença de Alzheimer
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article