Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness.
Invest Ophthalmol Vis Sci
; 54(8): 5829-35, 2013 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-23882692
ABSTRACT
PURPOSE:
We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT).METHODS:
Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT.RESULTS:
In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 µm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 µm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 µm).CONCLUSIONS:
Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fumar
/
Distrofia Endotelial de Fuchs
/
Córnea
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article