Influences of maternal B12 and methionine intake during gestation and lactation on testicular development of offspring in rats.
J Nutr Sci Vitaminol (Tokyo)
; 59(3): 238-42, 2013.
Article
em En
| MEDLINE
| ID: mdl-23883695
ABSTRACT
The influence of maternal vitamin B12 malnutrition on testicular development of offspring was examined using soy protein-based B12-deficient diets with or without 0.5% DL-methionine supplementation. Dams were fed the B12-deficient diet throughout gestation and lactation, whereas dams in a control group were fed a control diet which contained cyanocobalamin in the B12-deficient diet without methionine. Offspring born to dams fed the B12-deficient diet without methionine showed poor testicular development, e.g. decreased numbers of seminiferous tubules containing healthy spermatocytes and a high ratio of apoptotic cells per all germ cells. The abnormality was rarely observed in the group fed the B12-deficient diet with methionine. It was likely that the testicular abnormality of offspring was caused by B12-deficiency post partum and was prevented by the methionine supplementation. These observations suggested that maternal B12 nutritional status during the pre-weaning period is quite important for spermatogenesis of male offspring and that the requirement of B12 for testicular development is to produce active B12-dependent methionine synthase.
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Base de dados:
MEDLINE
Assunto principal:
Testículo
/
5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase
/
Vitamina B 12
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Deficiência de Vitamina B 12
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Lactação
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Fenômenos Fisiológicos da Nutrição Materna
/
Metionina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article