Long acting betaxolol ocular inserts based on polymer composite.
Curr Drug Deliv
; 10(4): 384-93, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23909665
ABSTRACT
Poor bioavailability and therapeutic response of conventional therapy due to many pre-corneal constraints necessitate the development of novel controlled and sustained ocular drug delivery to become a standard one in modern pharmaceutical era. This investigation aimed to study the drug release kinetics of betaxolol hydrochloride from a hydrophobic matrix system of PMMA cast with incorporating different proportions of polyethylene oxide (PEO) and evaluate its ability to improve ocular bioavailability and duration of action for the drug. Matrix type ocular inserts were prepared by the film casting technique and characterized in vitro by drug release studies using a flow through apparatus that simulated the eye conditions. All the formulations were subjected to physicochemical evaluation. Rabbit model with steroid induced glaucoma was used to establish in vivo efficacy of inserts. Polymer composition and concentration significantly affected the drug release based on change in diffusional path length and formation of gelaneous pores by polymer erosion. Formulations released the drug by non-fickian diffusion including anomalous transport (0.5
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Base de dados:
MEDLINE
Assunto principal:
Betaxolol
/
Sistemas de Liberação de Medicamentos
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Preparações de Ação Retardada
/
Anti-Hipertensivos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article