Evaluation of Albizia procera gum as compression coating material for colonic delivery of budesonide.
Int J Biol Macromol
; 61: 333-9, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23916644
ABSTRACT
The purpose of this research was to develop and evaluate Albizia procera gum as compression-coating polymer for colonic delivery of budesonide. Tablets were prepared by direct compression method using spray-dried lactose and microcrystalline cellulose as filler binders. The compatibility between the drug and the polymer was studied through TGA and FTIR spectroscopy. In vitro drug release were studied in dissolution media with or without 2% rat cecal contents while in vivo X-ray study was conducted on rabbits. The results indicate that procera gum and the drug were compatible with each other and tablet coated with procera gum was suitable for colonic delivery of drugs.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
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Budesonida
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Albizzia
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Gomas Vegetais
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article