Rapid emergence of resistance to linezolid and mutator phenotypes in Staphylococcus aureus isolates from an adult cystic fibrosis patient.
Antimicrob Agents Chemother
; 57(10): 5186-8, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23917314
ABSTRACT
Linezolid has emerged as an important therapeutic option for the treatment of Staphylococcus aureus in patients with cystic fibrosis. We report the rapid emergence, upon treatment with linezolid, of linezolid-resistant S. aureus clinical isolates through the accumulation of resistance-associated 23S rRNA mutations, together with acquisition of an altered mutator phenotype.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Fibrose Cística
/
Antibacterianos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article