Interleukin 10 (IL10) and transforming growth factor ß1 (TGFß1) gene polymorphisms in persistent IgE-mediated cow's milk allergy.
Clinics (Sao Paulo)
; 68(7): 1004-9, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23917667
ABSTRACT
OBJECTIVES:
The aim of this cross-sectional study was to evaluate whether interleukin 10 (IL10) and transforming growth factor ß1 (TGFß1) gene polymorphisms were associated with persistent IgE-mediated cow's milk allergy in 50 Brazilian children. The diagnostic criteria were anaphylaxis triggered by cow's milk or a positive double-blind, placebo-controlled food challenge. Tolerance was defined as the absence of a clinical response to a double-blind, placebo-controlled food challenge or cow's milk exposure.METHOD:
The genomic DNA of the 50 patients and 224 healthy controls (HCs) was used to investigate five IL10 gene polymorphisms (-3575A/T, -2849A/G, -2763A/C, -1082G/A, -592C/A) and one TGFß1 polymorphism (-509C/T).RESULTS:
Among the five IL10 polymorphisms analyzed, homozygosis for the G allele at the -1082 position was significantly higher in the patients compared with the healthy controls (p=0.027) and in the persistent cow's milk allergy group compared with the healthy controls (p=0.001).CONCLUSIONS:
Homozygosis for the G allele at the IL10 -1082G/A polymorphism is associated with the persistent form of cow's milk allergy.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Imunoglobulina E
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Hipersensibilidade a Leite
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Interleucina-10
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Polimorfismo de Nucleotídeo Único
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Fator de Crescimento Transformador beta1
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article