Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy.
J Cent Nerv Syst Dis
; 5: 25-30, 2013.
Article
em En
| MEDLINE
| ID: mdl-23926443
ABSTRACT
Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD.
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MEDLINE
Idioma:
En
Ano de publicação:
2013
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Article