Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties.
Eur J Heart Fail
; 16(1): 76-85, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-23928650
ABSTRACT
Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antagonistas Adrenérgicos beta
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Insuficiência Cardíaca
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Frequência Cardíaca
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article