Differentiation state affects morphine induced cell regulation in neuroblastoma cultured cells.
Neurosci Lett
; 555: 51-6, 2013 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-23932892
ABSTRACT
Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer in infancy. Our purpose was to investigate in vitro how cancer cell survival occurs in presence of morphine in undifferentiated and differentiated SHSY-5Y human neuroblastoma cultured cell line. Exposure of differentiated cells to morphine dose-dependently induced apoptosis in these cells through c-Jun N-terminal kinase (JNK)/caspase pathway. Otherwise, morphine induced activation for mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway, caused positive regulation of cell survival in undifferentiated cells. Therefore, cell differentiation state bimodally affects the cellular regulation activity triggered by morphine in isolated cultured neuroblastoma cells raising concerns about the application of morphine to this type of cancer patients.
Palavras-chave
Cell differentiation; Cell survival; ERK; GAP43; GFAP; JNK; MAPK; Morphine; NF-M; NSE; Neuroblastoma cells; Neuron-Specific Enolase; PPAR; RA; Signaling pathway; anti-Growth-Associated Protein 43; c-Jun N-terminal kinase; extracellular signal-regulated kinase; glial fibrillary acidic protein; mitogen-activated protein kinase; morphine; morphine HCl; neurofilament M; peroxisome proliferator-activated receptors; retinoic acid; µ opioid receptor; µOR
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Sobrevivência Celular
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Apoptose
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Analgésicos Opioides
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Morfina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article