Genome-wide association study identifies three novel loci for type 2 diabetes.
Hum Mol Genet
; 23(1): 239-46, 2014 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-23945395
ABSTRACT
Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were selected and taken forward to follow-up analyses. Combined discovery and follow-up analyses (30 392 cases and 34 814 controls) identified three new loci with genome-wide significance, which were MIR129-LEP [rs791595; risk allele = A; risk allele frequency (RAF) = 0.080; P = 2.55 × 10(-13); odds ratio (OR) = 1.17], GPSM1 [rs11787792; risk allele = A; RAF = 0.874; P = 1.74 × 10(-10); OR = 1.15] and SLC16A13 (rs312457; risk allele = G; RAF = 0.078; P = 7.69 × 10(-13); OR = 1.20). This study demonstrates that GWASs based on the imputation of genotypes using modern reference haplotypes such as that from the 1000 Genomes Project data can assist in identification of new loci for common diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Dissociação do Nucleotídeo Guanina
/
Transportadores de Ácidos Monocarboxílicos
/
Diabetes Mellitus Tipo 2
/
Estudo de Associação Genômica Ampla
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article