HIV infection is associated with reduced pulmonary diffusing capacity.
J Acquir Immune Defic Syndr
; 64(3): 271-8, 2013 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-23979001
ABSTRACT
INTRODUCTION:
Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited.OBJECTIVES:
To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals.METHODS:
Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires.RESULTS:
Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO was 69% in HIV-infected vs. 76% in HIV-uninfected men (P < 0.001). A moderately to severely reduced DLCO of ≤60% was observed in 30% of HIV-infected compared with 18% of HIV-uninfected men (P < 0.001), despite the fact that 89% of those with HIV were on antiretroviral therapy. A reduced DLCO was significantly associated with HIV and CD4 cell count in linear regression adjusting for smoking and other confounders. The DLCO was lowest in HIV-infected men with CD4 cell counts <200 cells per microliter compared with those with CD4 cell counts ≥200 cells per microliter and to HIV-uninfected men. Respiratory symptoms of cough, phlegm and dyspnea were more prevalent in HIV-infected patients particularly those with abnormal pulmonary function compared with HIV-uninfected patients.CONCLUSIONS:
HIV infection is an independent risk factor for reduced DLCO, particularly in individuals with a CD4 cell count below 200 cells per microliter. Abnormalities in pulmonary function among HIV-infected patients manifest clinically with increased respiratory symptoms. Mechanisms accounting for the reduced DLCO require further evaluation.
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Base de dados:
MEDLINE
Assunto principal:
Fumar
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Infecções por HIV
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Capacidade de Difusão Pulmonar
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Tosse
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Doença Pulmonar Obstrutiva Crônica
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Dispneia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article