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Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer.
Etemadmoghadam, Dariush; Au-Yeung, George; Wall, Meaghan; Mitchell, Chris; Kansara, Maya; Loehrer, Elizabeth; Batzios, Crisoula; George, Joshy; Ftouni, Sarah; Weir, Barbara A; Carter, Scott; Gresshoff, Irma; Mileshkin, Linda; Rischin, Danny; Hahn, William C; Waring, Paul M; Getz, Gad; Cullinane, Carleen; Campbell, Lynda J; Bowtell, David D.
Afiliação
  • Etemadmoghadam D; Authors' Affiliations: Peter MacCallum Cancer Centre, East Melbourne; Victorian Cancer Cytogenetics Service, St Vincent's Hospital, Melbourne; Sir Peter MacCallum Department of Oncology; Departments of Pathology, Biochemistry and Molecular Biology, and Medicine; Centre for Translational Pathology, University of Melbourne, Parkville, Victoria, Australia; Dana-Farber Cancer Institute, Boston; and The Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
Clin Cancer Res ; 19(21): 5960-71, 2013 Nov 01.
Article em En | MEDLINE | ID: mdl-24004674
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Poliploidia / Amplificação de Genes / Proteínas Oncogênicas / Resistencia a Medicamentos Antineoplásicos / Ciclina E / Inibidores de Proteínas Quinases / Quinase 2 Dependente de Ciclina Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Poliploidia / Amplificação de Genes / Proteínas Oncogênicas / Resistencia a Medicamentos Antineoplásicos / Ciclina E / Inibidores de Proteínas Quinases / Quinase 2 Dependente de Ciclina Idioma: En Ano de publicação: 2013 Tipo de documento: Article