[Determination pharmacokinetics parameters of raw and different processed epimediums by pharmacology effect method].
Zhong Yao Cai
; 36(3): 370-3, 2013 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-24010315
ABSTRACT
OBJECTIVE:
To determine the pharmacokinetics parameters of raw and different processed epimediums with pharmacology effect method.METHODS:
The kidney-yang deficiency model mice induced with hydrocortisone was used and oxidative stress level was taken as index to estimate main pharmacokinetics parameters of raw and different processed epimediums.RESULTS:
After raw and different processed epimediums po. in mice, the main pharmacokinetics parameters were raw epimedium AUC(0-t) = 184.77 (g/kg) x h, AUC(0-infinity) = 342.30 (g/kg) x h, MRT(0-t) = 5.95 h, MRT (0-infinity) = 28.58 h,Tmax, = 0.75 h, Cmax = 57.67 g/kg; Fried epimedium AUC(0-t) = 208.08 (g/kg) x h, AUC(0-infinity) = 523.95 (g/kg) x h, MRT(0-t) = 5.86 h, MRT(0-infinity) = 22.55h, Tmax = 1 h, Cmax = 62.53 g/kg; Fat-fried epimedium AUC (0-t) = 232.17 (g/kg) x h, AUC(0-infinity) = 629.96 (g/kg) x h, MRT(0-t) = 5.28 h, MRT(0-infinity) = 19.62 h, Tmax = 1.5 h, Cmax = 81.84 g/kg.CONCLUSION:
The differences of Cmax and AUC between processed products and raw products are significant, and the sequence is as follows fat-fried products > fried products > raw products.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Deficiência da Energia Yang
/
Epimedium
/
Malondialdeído
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article