A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib.
Chem Commun (Camb)
; 49(83): 9570-2, 2013 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-24018863
ABSTRACT
In this study, two phthalocyanine-erlotinib conjugates linked by an oligoethylene glycol chain have been synthesised and fully characterised. Having erlotinib as the targeting moiety, the two conjugates exhibited high specific affinity to HepG2 cancer cells and tumour tissues, therefore leading to high photodynamic activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Quinazolinas
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Fármacos Fotossensibilizantes
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Indóis
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Antineoplásicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article