A novel polyrotaxane-based delivery system for scutellarin: preparation, characterization, and in vitro evaluation.
Carbohydr Res
; 380: 149-55, 2013 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-24036381
ABSTRACT
The safe and effective polyrotaxane-based drug delivery system could potentially increase the antiproliferative activity of antitumor medicine. A novel scutellarin-polyrotaxane (SCU-PR), in which scutellarin (SCU) was covalently bound to one of the hydroxyl groups of polyrotaxane (PR), was synthesized, and its characterization was further investigated by NMR, XRD, TG, DSC. The cytotoxicity of SCU-PR was assessed in vitro using human HCT116 and LOVO cell lines in results that the IC50 values of SCU-PR (1.03×10(-6) and 1.01×10(-6)mol/L, respectively), which compared with those of free SCU (7.80×10(-5) and 7.70×10(-5)mol/L, respectively), were lower. The valuable properties of SCU-PR will be potentially useful for its application on human colon cancer chemotherapies.
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Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
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Poloxâmero
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Ciclodextrinas
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Rotaxanos
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Apigenina
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Glucuronatos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article