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Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.
Colotti, Gianni; Ilari, Andrea; Fiorillo, Annarita; Baiocco, Paola; Cinellu, Maria Agostina; Maiore, Laura; Scaletti, Federica; Gabbiani, Chiara; Messori, Luigi.
Afiliação
  • Colotti G; Institute of Molecular Biology & Pathology; National Research Council (CNR); Institute Pasteur Fondazione Cenci Bolognetti; Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome (Italy). gianni.colotti@uniroma1.it.
ChemMedChem ; 8(10): 1634-7, 2013 Oct.
Article em En | MEDLINE | ID: mdl-24039168
ABSTRACT
Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Complexos de Coordenação / Ouro / NADH NADPH Oxirredutases / Antiprotozoários Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Complexos de Coordenação / Ouro / NADH NADPH Oxirredutases / Antiprotozoários Idioma: En Ano de publicação: 2013 Tipo de documento: Article