Effects of clinical isolates of Streptococcus pneumoniae on THP-1 human monocytic cells.
Mol Med Rep
; 8(5): 1570-4, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24045590
ABSTRACT
Twentythree clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The production of interleukin (IL)8, intracellular adhesion molecule1 (ICAM1) and IL10 in THP1 cells following stimulation with the SP suspension was analyzed by an enzyme-linked immunosorbent assay. The concentrations of IL8, ICAM1 and IL10 from the THP1 monocytes were greater than those of the blank control following stimulation with the SP suspension. No significant difference was identified in the levels of IL8, ICAM1 and IL10 secretion between THP1 monocytes stimulated by bloodborne SP (bbSP) and sputumborne SP (sbSP).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Pneumocócica
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Escarro
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Streptococcus pneumoniae
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Monócitos
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Interleucina-8
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Interleucina-10
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Molécula 1 de Adesão Intercelular
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article