[Non-animal toxicology in the safety testing of chemicals]. / Eläinkokeeton toksikologia kemikaalien turvallisuustestauksessa.
Duodecim
; 129(16): 1686-94, 2013.
Article
em Fi
| MEDLINE
| ID: mdl-24069638
ABSTRACT
There is an urgent need to develop predictive test methods better than animal experiments for assessing the safety of chemical substances to man. According to today's vision this is achieved by using human cell based tissue and organ models. In the new testing strategy the toxic effects are assessed by the changes in the critical parameters of the cellular biochemical routes (AOP, adverse toxic outcome pathway-principle) in the target tissues. In vitro-tests are rapid and effective, and with them automation can be applied. The change in the testing paradigm is supported by all stakeholders scientists, regulators and people concerned on animal welfare.
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Base de dados:
MEDLINE
Assunto principal:
Testes de Toxicidade
/
Alternativas aos Testes com Animais
Idioma:
Fi
Ano de publicação:
2013
Tipo de documento:
Article