Insights on the genotype distribution among Cryptococcus neoformans and C. gattii Portuguese clinical isolates.
Curr Microbiol
; 68(2): 199-203, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24077953
ABSTRACT
This study provides a comprehensive picture of the C. neoformans/C. gattii molecular types most often associated with human cryptococcosis in Portugal and assesses the impact of C. gattii in these infections. One hundred and twenty-two clinical isolates, from distinct patients, were identified as C. neoformans and genotyped by URA5-RFLP, with the molecular types VNI (45.5 %) and VNIII (30.9 %) being the most commonly found ones. The molecular types VNII (11.4 %) and VNIV (11.4 %) were less abundant. One patient was found to be infected with a VGII isolate. This patient exhibited unusual clinical symptoms of cryptococcosis, reinforcing the suspicion for the presence of a different genotypic pattern, as determined afterwards. This case was detected in 2007 and is the first report of a potential autochthonous C. gattii infection case in Portugal, as the patient revealed no historical record of travelling outside the country.
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Base de dados:
MEDLINE
Assunto principal:
Criptococose
/
Cryptococcus
/
Cryptococcus neoformans
/
Genótipo
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article