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Use of inclusion complex of cyclodextrin with ambenonium to improve the treatment of anticholinesterase poisoning.
Yudin, M A; Ivanov, I M; Nikiforov, A S; Kornyukhina, T M; Tyunin, M A.
Afiliação
  • Yudin MA; Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, St. Petersburg, Russia. mihei_bridge@mail.ru.
Bull Exp Biol Med ; 155(2): 218-20, 2013 Jun.
Article em En | MEDLINE | ID: mdl-24130994
The complex of ambenonium with methyl-ß-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy significantly reduces mortality in animals during experimental anticholinesterase poisoning in comparison with the controls.
Assuntos
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Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Inibidores da Colinesterase / Beta-Ciclodextrinas / Cloreto de Ambenônio Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Inibidores da Colinesterase / Beta-Ciclodextrinas / Cloreto de Ambenônio Idioma: En Ano de publicação: 2013 Tipo de documento: Article