High expression of leptin receptor leads to temozolomide resistance with exhibiting stem/progenitor cell features in gliobalastoma.

Han, Guosheng; Wang, Laixing; Zhao, Wenyuan; Yue, Zhijian; Zhao, Rui; Li, Yanan; Zhou, Xiaoping; Hu, Xiaowu; Liu, Jianmin

Han, Guosheng; Wang, Laixing; Zhao, Wenyuan; Yue, Zhijian; Zhao, Rui; Li, Yanan; Zhou, Xiaoping; Hu, Xiaowu; Liu, Jianmin.

Afiliação

Han G; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Wang L; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Zhao W; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Yue Z; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Zhao R; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Li Y; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Zhou X; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Hu X; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.
Liu J; Department of Neurosurgery; Changhai Hospital; Second Military Medical University; Shanghai, China.

Cell Cycle ; 12(24): 3833-40, 2013 Dec 15.

Article em En | MEDLINE | ID: mdl-24131927

Assuntos

Antineoplásicos Alquilantes/farmacologia; Neoplasias Encefálicas/patologia; Dacarbazina/análogos & derivados; Resistencia a Medicamentos Antineoplásicos; Glioblastoma/patologia; Células-Tronco Neoplásicas/efeitos dos fármacos; Receptores para Leptina/genética; Antígeno AC133; Antígenos CD/metabolismo; Apoptose/efeitos dos fármacos; Neoplasias Encefálicas/metabolismo; Linhagem Celular Tumoral/efeitos dos fármacos; Dacarbazina/farmacologia; Glioblastoma/metabolismo; Glicoproteínas/metabolismo; Humanos; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Fator 3 de Transcrição de Octâmero/metabolismo; Peptídeos/metabolismo; Receptores para Leptina/metabolismo; Fatores de Transcrição SOXB1/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais; Temozolomida

Palavras-chave

STAT3; chemoresistance; glioblastoma stem cells; leptin receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias Encefálicas / Glioblastoma / Resistencia a Medicamentos Antineoplásicos / Antineoplásicos Alquilantes / Dacarbazina / Receptores para Leptina Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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