T-lymphocyte recognition of beta cells in type 1 diabetes: clinical perspectives.
Diabetes Metab
; 39(6): 459-66, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24139825
ABSTRACT
Type 1 diabetes (T1D) is an autoimmune disease characterized by the activation of lymphocytes against pancreatic ß cells. Landmarks in the history of T1D were the description of insulitis and of islet cell autoantibodies, and report an association between T1D and a limited number of HLA alleles. Another step was the study of T-lymphocytes, now known to be central to the disease process of T1D whether in mice or men. In humans, T-lymphocytes, and especially CD8⺠T-cells, are predominant in insulitis. The characterization of antigenic fragments--peptides--recognized by T-cells paves the way towards new assays for predicting T1D and its prevention using antigen- or peptide-specific immunotherapy, while avoiding side effects that may counteract the limited efficacy of immunosuppression and immunomodulation in preserving ß-cells from autoimmune destruction in recent-onset T1D patients. The current need for new preclinical models for testing strategies of antigen-specific immune tolerance is also highlighted.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Diabetes Mellitus Tipo 1
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Células Secretoras de Insulina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article