Interleukin-32 contributes to invasion and metastasis of primary lung adenocarcinoma via NF-kappaB induced matrix metalloproteinases 2 and 9 expression.
Cytokine
; 65(1): 24-32, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24140068
ABSTRACT
Interleukin (IL)-32 is a novel proinflammatory cytokine, which has been shown to play an important role in tumor growth and metastasis. Here, we discovered that IL-32 was aberrantly over-expressed in lung adenocarcinoma tissues and cell lines. Positive expression of IL-32 significantly correlated with the clinical staging, and lymph node and distant metastases. High expression of IL-32 was an independent indicator of poor prognosis in lung adenocarcinoma patients. Moreover, IL-32-facilitated cell migration and invasion in vitro was mediated through transactivation of the nuclear transcription factor (NF)-κB signaling pathway and subsequent upregulation of matrix metalloproteinase (MMP)-2 and MMP9 expression. These studies demonstrate that IL-32 plays a role in the tumor-associated inflammatory microenvironment and that overexpression of IL-32 contributes to invasion and metastasis in primary lung adenocarcinoma, suggesting that it may have clinical utility as a prognostic biomarker and potential target for immunotherapy in lung adenocarcinoma.
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Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
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Interleucinas
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
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Subunidade p50 de NF-kappa B
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Fator de Transcrição RelA
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Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article