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Anti-3-[(18)F]FACBC positron emission tomography-computerized tomography and (111)In-capromab pendetide single photon emission computerized tomography-computerized tomography for recurrent prostate carcinoma: results of a prospective clinical trial.
Schuster, David M; Nieh, Peter T; Jani, Ashesh B; Amzat, Rianot; Bowman, F Dubois; Halkar, Raghuveer K; Master, Viraj A; Nye, Jonathon A; Odewole, Oluwaseun A; Osunkoya, Adeboye O; Savir-Baruch, Bital; Alaei-Taleghani, Pooneh; Goodman, Mark M.
Afiliação
  • Schuster DM; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia. Electronic address: dschust@emory.edu.
  • Nieh PT; Department of Urology, Emory University, Atlanta, Georgia.
  • Jani AB; Department of Radiation Oncology, Emory University, Atlanta, Georgia.
  • Amzat R; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
  • Bowman FD; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia.
  • Halkar RK; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
  • Master VA; Department of Urology, Emory University, Atlanta, Georgia.
  • Nye JA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
  • Odewole OA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
  • Osunkoya AO; Department of Urology, Emory University, Atlanta, Georgia; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia.
  • Savir-Baruch B; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
  • Alaei-Taleghani P; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
  • Goodman MM; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.
J Urol ; 191(5): 1446-53, 2014 May.
Article em En | MEDLINE | ID: mdl-24144687
PURPOSE: We prospectively evaluated the amino acid analogue positron emission tomography radiotracer anti-3-[(18)F]FACBC compared to ProstaScint® ((111)In-capromab pendetide) single photon emission computerized tomography-computerized tomography to detect recurrent prostate carcinoma. MATERIALS AND METHODS: A total of 93 patients met study inclusion criteria who underwent anti-3-[(18)F]FACBC positron emission tomography-computerized tomography plus (111)In-capromab pendetide single photon emission computerized tomography-computerized tomography for suspected recurrent prostate carcinoma within 90 days. Reference standards were applied by a multidisciplinary board. We calculated diagnostic performance for detecting disease. RESULTS: In the 91 of 93 patients with sufficient data for a consensus on the presence or absence of prostate/bed disease anti-3-[(18)F]FACBC had 90.2% sensitivity, 40.0% specificity, 73.6% accuracy, 75.3% positive predictive value and 66.7% negative predictive value compared to (111)In-capromab pendetide with 67.2%, 56.7%, 63.7%, 75.9% and 45.9%, respectively. In the 70 of 93 patients with a consensus on the presence or absence of extraprostatic disease anti-3-[(18)F]FACBC had 55.0% sensitivity, 96.7% specificity, 72.9% accuracy, 95.7% positive predictive value and 61.7% negative predictive value compared to (111)In-capromab pendetide with 10.0%, 86.7%, 42.9%, 50.0% and 41.9%, respectively. Of 77 index lesions used to prove positivity histological proof was obtained in 74 (96.1%). Anti-3-[(18)F]FACBC identified 14 more positive prostate bed recurrences (55 vs 41) and 18 more patients with extraprostatic involvement (22 vs 4). Anti-3-[(18)F]FACBC positron emission tomography-computerized tomography correctly up-staged 18 of 70 cases (25.7%) in which there was a consensus on the presence or absence of extraprostatic involvement. CONCLUSIONS: Better diagnostic performance was noted for anti-3-[(18)F]FACBC positron emission tomography-computerized tomography than for (111)In-capromab pendetide single photon emission computerized tomography-computerized tomography for prostate carcinoma recurrence. The former method detected significantly more prostatic and extraprostatic disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Radioisótopos de Índio / Ácidos Carboxílicos / Carcinoma / Tomografia Computadorizada por Raios X / Tomografia Computadorizada de Emissão de Fóton Único / Ciclobutanos / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Anticorpos Monoclonais Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Radioisótopos de Índio / Ácidos Carboxílicos / Carcinoma / Tomografia Computadorizada por Raios X / Tomografia Computadorizada de Emissão de Fóton Único / Ciclobutanos / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Anticorpos Monoclonais Idioma: En Ano de publicação: 2014 Tipo de documento: Article